ISSN 1662-4009 (online)

ey0019.14-7 | Steroidogenesis and beyond | ESPEYB19

14.7. Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

B Ashley , C Simner , A Manousopoulou , C Jenkinson , F Hey , JM Frost , FI Rezwan , CH White , EM Lofthouse , E Hyde , LDF Cooke , S Barton , P Mahon , EM Curtis , RJ Moon , SR Crozier , HM Inskip , KM Godfrey , JW Holloway , C Cooper , KS Jones , RM Lewis , M Hewison , SDD Garbis , MR Branco , NC Harvey , JK Cleal

eLife 2022;11:e71094 doi: 10.7554/eLife.71094Brief summary: Using placental perfusion, placental fragment culture and primary term human cytotrophoblast culture experiments, the authors signify the relationship between maternal vitamin D, placental vitamin D metabolism and fetal vitamin D exposure.In this study, the uptake of radio-labelled vitamin D (13C-25(OH)D...

ey0016.15-5 | (1) | ESPEYB16

15.5. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis

E Voerman , S Santos , B Patro Golab , P Amiano , F Ballester , H Barros , A Bergstrom , MA Charles , L Chatzi , C Chevrier , GP Chrousos , E Corpeleijn , N Costet , S Crozier , G Devereux , M Eggesbo , S Ekstrom , MP Fantini , S Farchi , F Forastiere , V Georgiu , KM Godfrey , D Gori , V Grote , W Hanke , I Hertz-Picciotto , B Heude , D Hryhorczuk , RC Huang , H Inskip , N Iszatt , AM Karvonen , LC Kenny , B Koletzko , LK Kupers , H Lagstrom , I Lehmann , P Magnus , R Majewska , J Makela , Y Manios , FM McAuliffe , SW McDonald , J Mehegan , M Mommers , CS Morgen , TA Mori , G Moschonis , D Murray , CN Chaoimh , EA Nohr , AM Nybo Andersen , E Oken , A Oostvogels , A Pac , E Papadopoulou , J Pekkanen , C Pizzi , K Polanska , D Porta , L Richiardi , SL Rifas-Shiman , L Ronfani , AC Santos , M Standl , C Stoltenberg , E Thiering , C Thijs , M Torrent , SC Tough , T Trnovec , S Turner , L van Rossem , A von Berg , M Vrijheid , TGM Vrijkotte , J West , A Wijga , J Wright , O Zvinchuk , TIA Sorensen , DA Lawlor , R Gaillard , VWV Jaddoe

To read the full abstract: PLoS Med, 2019;16:e1002744These investigators painstakingly collated individual-level data from 37 pregnancy and birth cohort studies from Europe, North America, and Australia, comprising 162,129 mothers and their children, in order to identify the optimal levels gestational weight gain in relation to risk of offspring obes...